Quick question: Why do people line up or huddle around an airport gate before they are called to board? The plane is not leaving until everyone has boarded, so why would you want to sit even longer in a cramped up airplane than is absolutely necessary?
I contemplated these questions and other airport mysteries (like who would pay a $38 service fee for changing Canadian to US currency) while recently sitting in airports for 7 hours and 5 hours on two separate trips.
Fortunately, both flights were worth while since one was a flight home where home made meals and warm fireplaces greeted my new family of 3 and the second was for a job that I am quite interested in at Boston. Luckily, another interview I had arranged did not require a flight so my sanity was slightly saved.
I would say that both interviews went fairly well, and overall I actually enjoyed the experience. Doing a PhD (or any large project I suppose), you tend to lose sight of the accomplishments that you have made along the way. Getting a chance to present my work to an audience that is genuinely interested (not just lab mates that have to be in attendance) does not happen that often and even though it can be a bit stressful, I usually find it rewarding.
A post-doc's point of view on bioinformatics, evolution, and microbial diversity; with an interest in cutting edge computer tools that make them all a bit easier.
Wednesday, January 7, 2009
Wednesday, December 3, 2008
Two thumbs up for CiteULike
After getting tired of the slowness and lack of features of Connotea I decided to try out CiteULike. My only regret is that I wish I made the switch about 6 months ago, since CiteULike seems superior to Connotea in almost every way.
In particular, I really like the built in priority list for indicating the level of importance for me to read a certain article. This is much better than my old Connotea method of using a "to_read" tag. Also, the use of tag clouds (instead of simple lists) not only for my personal tags but also for authors is a really nice feature. I was really surprised to see that you can upload a pdf of the paper being cited for storage on CiteULike. I'm not sure how much I will use this feature, but it is a nice option for those papers that you might not have easy access to all the time. Lastly, the search function is simple yet effective and the site runs smoothly without any waiting or timeouts.
The transfer of my bookmarks from Connotea to CiteULike was easy. I simply exported my bookmarks from Connotea in RIS format (which of course took about a minute of waiting) and then imported them into CiteULike. The only small hiccup is that CiteULike doesn't handle multiple words as a single tag (ie. no spaces allowed), but CiteULike did convert all of these cases using dashes instead of spaces.
Overall, I am a happy social bookmarker again and you can follow what I am reading here:
http://www.citeulike.org/user/mlangill
In particular, I really like the built in priority list for indicating the level of importance for me to read a certain article. This is much better than my old Connotea method of using a "to_read" tag. Also, the use of tag clouds (instead of simple lists) not only for my personal tags but also for authors is a really nice feature. I was really surprised to see that you can upload a pdf of the paper being cited for storage on CiteULike. I'm not sure how much I will use this feature, but it is a nice option for those papers that you might not have easy access to all the time. Lastly, the search function is simple yet effective and the site runs smoothly without any waiting or timeouts.
The transfer of my bookmarks from Connotea to CiteULike was easy. I simply exported my bookmarks from Connotea in RIS format (which of course took about a minute of waiting) and then imported them into CiteULike. The only small hiccup is that CiteULike doesn't handle multiple words as a single tag (ie. no spaces allowed), but CiteULike did convert all of these cases using dashes instead of spaces.
Overall, I am a happy social bookmarker again and you can follow what I am reading here:
http://www.citeulike.org/user/mlangill
Saturday, November 29, 2008
Firefox & Thunderbird Addons
Yesterday, I was watching someone on the bus scroll on their iPhone and I was thinking "Why doesn't my scrolling look that smooth on my laptop"? After a quick search I found the "Yet Another Smooth Scrolling" add-on for Firefox and it works perfectly!
I have tried lots of different add-ons, but the ones that I find essential are:
Firefox (in order of importance)
-Foxmarks Bookmark Synchronizer - allows backing up and syncing of bookmarks (and recently passwords) between computers
Adblock Plus - blocks all of those annoying ads
Download StatusBar - makes a smaller download status bar
Yet Another Smooth Scrolling - smooth scrolling
Greasemonkey - allows tons of different of scripts (including some nice ones for browsing Craigslist)
Thunderbird
Slideshow - allows easy viewing and resizing attached pictures
Signature Switch - a single button that quickly turns on or off your signature (and allows multiple signatures)
If you have any other essential add-ons, please let me know!
I have tried lots of different add-ons, but the ones that I find essential are:
Firefox (in order of importance)
-Foxmarks Bookmark Synchronizer - allows backing up and syncing of bookmarks (and recently passwords) between computers
Adblock Plus - blocks all of those annoying ads
Download StatusBar - makes a smaller download status bar
Yet Another Smooth Scrolling - smooth scrolling
Greasemonkey - allows tons of different of scripts (including some nice ones for browsing Craigslist)
Thunderbird
Slideshow - allows easy viewing and resizing attached pictures
Signature Switch - a single button that quickly turns on or off your signature (and allows multiple signatures)
If you have any other essential add-ons, please let me know!
Friday, November 28, 2008
Sorry Connotea, it's not you, it's me.
I used to really like Connotea and the idea of being able to easily bookmark and share journal articles was what drove me to encourage many people in my lab to start using it. I truly believed it would evolve into a tool that would be essential for researchers and would be a major improvement to existing methods of tracking new papers.
Well, boy was I wrong. I haven't seen any improvements in Connotea for at least a year including a search engine that would be better replaced by Google. Even worse for the past few months Connotea website has been getting slower so that instead of looking up my papers there I just go back to searching Pubmed. Finally, for the past few days Connotea seems completelly useless so that papers I was hoping to cite for my near future thesis writing days are inaccessible.
Like any bad relationship I was hoping it would get better over time, but I have waited long enough and I'm breaking it off before I get any more committed. If the site does ever become accessible again I plan on exporting my bookmarks and taking them elsewhere. Any recommendations?
Well, boy was I wrong. I haven't seen any improvements in Connotea for at least a year including a search engine that would be better replaced by Google. Even worse for the past few months Connotea website has been getting slower so that instead of looking up my papers there I just go back to searching Pubmed. Finally, for the past few days Connotea seems completelly useless so that papers I was hoping to cite for my near future thesis writing days are inaccessible.
Like any bad relationship I was hoping it would get better over time, but I have waited long enough and I'm breaking it off before I get any more committed. If the site does ever become accessible again I plan on exporting my bookmarks and taking them elsewhere. Any recommendations?
Tuesday, November 18, 2008
IslandViewer
My most recent research has resulted in website for viewing predictions of genomic islands (GIs), large regions of horizontal gene transfer, in bacterial genomes. IslandViewer integrates three different methods of GI detection IslandPick, SIGI-HMM, and IslandPath-DIMOB. SIGI-HMM and IslandPath-DIMOB use sequence composition bias to detect GIs and were found to be the most accurate in a recent publication. IslandPick is a method I recently developed that uses comparative genomics to find GIs by identifying regions that are present in one genome but absent from several related genomes.

Predictions for all three tools are pre-computed for all sequenced bacterial genomes (those available from NCBI Microbial genomes). Also, users can submit their own newly sequenced genome for analysis and receive an email when complete (usually within a couple of hours).
Update:IslandViewer has been published in Bioinformatics!
Any feedback or comments on the design or usefulness on the website is appreciated!

Predictions for all three tools are pre-computed for all sequenced bacterial genomes (those available from NCBI Microbial genomes). Also, users can submit their own newly sequenced genome for analysis and receive an email when complete (usually within a couple of hours).
Update:IslandViewer has been published in Bioinformatics!
Any feedback or comments on the design or usefulness on the website is appreciated!
Friday, November 14, 2008
My New Little Scientist
My first baby was born on Nov. 5th weighing in at 7lbs. After much debate during the pregnancy my wife and I decided to name him Gavin Nathaniel Langille. The first week was tiring of course, but I don't think I really noticed due all the excitement and the newness of it all. However, now that I am in the middle of the second week it is starting to catch up with me!
One thing about having the baby is that I am very focused on finishing my PhD and I am in serious job hunt mode. People keep asking me about what type of position I am looking for. The most likely is a post-doc in academia, but I haven't ruled out taking a job in industry. I have at least one post-doc position and one bioinformatics scientist position industry that I plan on applying by next week.
I would have to say that the biggest limitation for job hunting is location. Having a baby really is drawing me to move closer to home, Atlantic Canada, but I am still keeping a fairly wide search distance down to the Boston area.
Wednesday, October 1, 2008
Microbial Genomics Conference (Last Update)
I promised in a previous post to add more details about the Microbial Genomics conference in Lake Arrowhead. However, my wife went into pre-term labour, and is now on bed rest so I am a little short on time. I did give a conference review at a recent lab meeting so I thought I would post that as a quick substitute.
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